ProSeCa

Recovery of high value Proteins from Serum by innovative direct Capture techniques
Acronym: ProSeCa

Project coordinator
- Prof. Matthias Franzreb - Karlsruhe Institue of Technology, Eggenstein-Leopoldshafen - Germany

Project leaders
- Dr. Tim Overton - University of Birmingham - UK
- Dr. Tim Hobley - Technical University of Denmark, Lyngby - Denmark
- Dr. Peter Miethe - fzmb GmbH, Bad Langensalza - Germany
- Mr. Andreas Gütter - SENOVA Gesellschaft für Biossenschaft und Technik mbH Department, Weimar - Germany

The extraction of biopharmaceuticals from natural sources often employs overly complicated antiquated
procedures. The downstream processing of serum is a case in point; it comprises large numbers of steps
of low purification power and consequently delivers poor overall product yields.

Parallel advances in magnetic separation equipment and approaches to manufacture magnetic affinity
particles, funded through several national and EU funded projects lay the foundations for the proposed
work. Using magnetic bioseparation techniques, the consortium will seek to replace outdated organic
solvent based fractionation methods, which can inflict serious damage on especially prone protein
targets.

In ProSeCa, our combined expertise will be applied to the production of protein based veterinary
medicines from horse sera, centring on harmonious integrated use of: highly selective magnetic
adsorbents manufactured via: (i) chemical; (ii) biological; and (iii) mixed ‘biological/chemical’ routes; with
a fully automated and cGMP compliant magnetic separator.