BioProChemBB

Bio-based production of chemical building blocks: Corynebacterium glutamicum as a platform for new and efficient bioprocesses 
Acronym: BioProChemBB

Project coordinator

- Prof. Bernhard Eikmanns – University of Ulm – Germany

Project leaders

- Prof. Volker Wendisch – Westfälische Wilhelms-Universität Münster - Germany

- Prof. Juan Francisco Martín and Dr. Carlos Barreiro – INBIOTEC: Instituto de Biotecnologia de Léon – Spain

- Prof. Armel Guyonvarch – Universite Paris-Sud – France

- Dr. Marco Oldiges – Forschungszentrum Jülich – Germany

- Prof.dr. Michael Bott - Forschungszentrum Jülich – Germany

- Prof. Helena Santos and Dr. Ana Neves – Universidade Nova de Lisboa – Portugal

8. Prof. Jean-Louis Goergen – ENSAIA: Ecole Nationale d'Agronomie et des Industries Alimentaires – France

9. Dr. Adrie Straathof – Delft University of Technology – The Netherlands

Abstract

The project aims at developing Corynebacterium glutamicum as a designer bug, serving as a robust platform organism for new and efficient bioprocesses, such as the production of chemical building blocks from renewable resources. In an iterative way, we will construct and analyze C. glutamicum strains producing different dicarboxylic acids and amino acids. Additionally, the producer strains will be engineered to tolerate dicarboxylic acid stress, a relevant factor for process design and downstream processing of large-scale production processes. Using the producer strains, we will develop, scale-up and implement robust fermentation processes with integrated downstream processing solutions. The project has a high innovative potential for industrial applications and we regard the potential to improve the competitiveness of European companies as very high.

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